As you know, there are hundreds of
supplements
and herbal products out there. It is overwhelming to choose a product
that has all the essential ingredients that meet the quality standards
you deserve. We have done the research for you! We bring the following
products from manufacturers that emphasize quality, good manufacturing
standards and stand behind their products.
Double Strength! from Source Naturals. This SAMe is a stable, bioavailable form of S-adenosyl-L-methionine. These tablets are enteric coated and blister packed to prevent breakdown and inactivation of the ingredients. Dozens of clinical studies have demonstrated that SAM-e supports joint comfort, function and mobility in the spine, hips and knees. It is important to the joints because of its critical role in cartilage formation. Studies also show that SAMe helps support a positive outlook. It is able to cross the blood-brain barrier where it affects the synthesis and activation of various proteins, such as neurotransmitters. SAMe is present in every living cell in the body. However, levels of SAM-e tend to decline with age.
SAM-e and Homocysteine
One of the byproducts of normal SAMe metabolism is homocysteine. When there are adequate supplies of the metabolites, such as B6, B12 and folic acid, required for the synthesis and regeneration of SAMe, homocysteine breakdown occurs either through re-methylation or through trans-sulfuration. These processes turn homocysteine into glutathione, a powerful antioxidant. Therefore, supplementation with B6, B12 and Folic Acid or taking Homocysteine Protection Factors (PF) may insure proper function of SAMe.
SAM-e 200mg by Source Naturals. This SAMe is a stable, bioavailable form of S-adenosyl-L-methionine. These tablets are enteric coated and blister packed to prevent breakdown and inactivation of the ingredients. Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. It is important to the joints because of its critical role in cartilage formation. Studies also show that SAMe helps support a positive outlook. It is able to cross the blood-brain barrier where it affects the synthesis and activation of various proteins, such as neurotransmitters. SAMe is present in every living cell in the body. However, levels of SAMe tend to decline with age.
Pharmaceutical Grade Stabilized SAM-e by Jarrow Formulas. SAM-e (S-Adenosylmethionine) is a chiral molecule and therefore consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive.
Jarrow Formulas' SAM-e is made naturally by microbiological fermentation and then specially processed to preserve 68-80% (S,S) SAM-e, the highest active level available.
SAMe, 400 mg, 30 Enteric Coated Tablets - Doctor's BestBest SAM-e 400 contains 400 mg of active SAM-e in each tablet. Doctor’s Best utilizes only the highest quality Italian SAM-e available on the market. This ensures the most potent SAM-e product with the highest percentage of the active S,S form per serving.
S-Adenosyl Methionine (SAM-e) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. Methylation occurs billions of times daily in the many organs of the body. SAM-e is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAM-e is also required for the biosynthesis of critical neurotransmitters and hormones. SAM-e is the methyl donor that catalyzes the production of epinephrine, melatonin, glutathione and the amino acids cysteine and taurine. SAM-e is also known to upregulate the production of critical membrane phospholipids including phosphatidylcholine. SAM-e is also a sulfur donor and, for this reason, is critical for the formation of sulfur-containing proteoglycans in joint connective tissue.
All SAM-e supplements are not created equal
During the manufacture of SAM-e, two forms are produced known as the S,S and the R,S isomers. The S,S isomer is the biologically active form in the human body, whereas the R,S form is considered to be inactive. Best SAM-e 400 utilizes Italian SAM-e to yield the highest available percentage of the active pure S,S form on the market. Best SAM-e 400 contains an average of nearly 74% of the active S,S form. Other SAM-e products contain as little as only 50% of the active form. A higher content of the active form yields a more potent product.
The molecule SAM-e itself is highly unstable. It will degrade quickly in conditions of heat, light and moisture. To increase its stability, it must be formed into a salt. It is important to note that SAM-e used for dietary supplements exists in a number of salt forms. Best SAM-e utilizes the SAM-e tosylate disulfate salt form. This salt has been the most extensively utilized form in clinical trials of SAM-e.
Because of the unstable nature of pure SAM-e it is also highly susceptible to degradation in an acidic environment like the stomach. To be utilized effectively, it must pass through the stomach for absorption in the small intestine. For this reason, only enteric-coated formulas should be used. Best SAM-e tablets are enteric-coated to maximize the utilization and benefit of the SAM-e by the body.
